Same same but different: The evolution of TBP in archaea and their eukaryotic offspring
نویسندگان
چکیده
Transcription factors TBP and TF(II)B assemble with RNA polymerase at the promoter DNA forming the initiation complex. Despite a high degree of conservation, the molecular binding mechanisms of archaeal and eukaryotic TBP and TF(II)B differ significantly. Based on recent biophysical data, we speculate how the mechanisms co-evolved with transcription regulation and TBP multiplicity.
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2017